XRCC4 and PNKP

Number of citations of the paper that reports this interaction (PubMedID 15385968)
96

Data Source:
HPRD (in vitro, in vivo)

		XRCC4	PNKP
Description		X-ray repair cross complementing 4	polynucleotide kinase 3'-phosphatase
Image
GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex	Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane Site Of Double-strand Break
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Ligase Activity Identical Protein Binding FHA Domain Binding	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To X-ray Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Protein Localization To Site Of Double-strand Break	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Base-excision Repair, Gap-filling Double-strand Break Repair Via Nonhomologous End Joining Response To Oxidative Stress Response To Radiation Negative Regulation Of Protein ADP-ribosylation Dephosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation DNA Ligation Involved In DNA Repair Positive Regulation Of Telomerase Activity Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation Positive Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs		S-(Dimethylarsenic)Cysteine
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Osteoarthritis biomarkers ( 25057126) Squamous cell lung carcinoma ( 28604730) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)
Interacting Genes		24 interacting genes: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 FAM9B GSC2 GZMB HAUS2 IFFO1 KRT27 LIG4 MAGEA6 NBN NHEJ1 OGT PNKP PRKDC VIM	50 interacting genes: APP CACFD1 CAMK2B CARD10 CCDC14 CCDC43 CISD2 CNTROB COL17A1 DVL3 FADS6 GAS8 GZMK IKZF1 KANK2 KDM1A KLHL12 KRTAP4-12 LMNA MAGEA11 MCC MEOX2 MGST2 MSANTD4 MYOZ1 OBI1 OGT PICK1 PNMA5 POLB PSTPIP1 RPRM SFT2D1 SMAD5 SNX2 SP4 SUV39H1 SYNGR1 SYNGR3 SYP TARBP2 TBC1D1 THAP1 TMEM239 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639
Entrez ID		7518	11284
HPRD ID		15951	09284
Ensembl ID		ENSG00000152422	ENSG00000039650
Uniprot IDs		A0A024RAL0 A0A024RAP0 A0A024RAQ8 Q13426 Q7Z763	Q96T60
PDB IDs		1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03 4XA4 5CHX 5CJ0 5CJ4 5E50 5WJ7 5WLZ 6ABO	2BRF 2W3O
Enriched GO Terms of Interacting Partners?
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