PNKP and SYNGR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PNKP	SYNGR3
Description		polynucleotide kinase 3'-phosphatase	synaptogyrin 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane Site Of Double-strand Break	Synaptic Vesicle Integral Component Of Membrane Synaptic Vesicle Membrane Neuromuscular Junction
	Molecular Function	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity	Protein Binding SH2 Domain Binding Protein N-terminus Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Base-excision Repair, Gap-filling Double-strand Break Repair Via Nonhomologous End Joining Response To Oxidative Stress Response To Radiation Negative Regulation Of Protein ADP-ribosylation Dephosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation DNA Ligation Involved In DNA Repair Positive Regulation Of Telomerase Activity Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation Positive Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Neurotransmitter Uptake Substantia Nigra Development Positive Regulation Of Transporter Activity Regulated Exocytosis
Pathways		APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs
Diseases
GWAS
Interacting Genes		50 interacting genes: APP CACFD1 CAMK2B CARD10 CCDC14 CCDC43 CISD2 CNTROB COL17A1 DVL3 FADS6 GAS8 GZMK IKZF1 KANK2 KDM1A KLHL12 KRTAP4-12 LMNA MAGEA11 MCC MEOX2 MGST2 MSANTD4 MYOZ1 OBI1 OGT PICK1 PNMA5 POLB PSTPIP1 RPRM SFT2D1 SMAD5 SNX2 SP4 SUV39H1 SYNGR1 SYNGR3 SYP TARBP2 TBC1D1 THAP1 TMEM239 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639	14 interacting genes: ACSF2 ARFIP1 EHHADH GAD2 GLP1R HSBP1L1 MIDN MPP1 NDRG4 PLIN3 PNKP SH3GLB1 SPG21 TTPA
Entrez ID		11284	9143
HPRD ID		09284	06801
Ensembl ID		ENSG00000039650	ENSG00000127561
Uniprot IDs		Q96T60	O43761
PDB IDs		2BRF 2W3O
Enriched GO Terms of Interacting Partners?
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