PNKP and COL17A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PNKP	COL17A1
Description		polynucleotide kinase 3'-phosphatase	collagen type XVII alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane Site Of Double-strand Break	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Hemidesmosome Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Base-excision Repair, Gap-filling Double-strand Break Repair Via Nonhomologous End Joining Response To Oxidative Stress Response To Radiation Negative Regulation Of Protein ADP-ribosylation Dephosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation DNA Ligation Involved In DNA Repair Positive Regulation Of Telomerase Activity Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation Positive Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Cell-matrix Adhesion Epidermis Development Extracellular Matrix Organization Hemidesmosome Assembly
Pathways		APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	Collagen degradation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly Collagen chain trimerization
Drugs
Diseases
GWAS			Cardiac hypertrophy ( 21348951)
Interacting Genes		50 interacting genes: APP CACFD1 CAMK2B CARD10 CCDC14 CCDC43 CISD2 CNTROB COL17A1 DVL3 FADS6 GAS8 GZMK IKZF1 KANK2 KDM1A KLHL12 KRTAP4-12 LMNA MAGEA11 MCC MEOX2 MGST2 MSANTD4 MYOZ1 OBI1 OGT PICK1 PNMA5 POLB PSTPIP1 RPRM SFT2D1 SMAD5 SNX2 SP4 SUV39H1 SYNGR1 SYNGR3 SYP TARBP2 TBC1D1 THAP1 TMEM239 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639	18 interacting genes: ACTN1 ACTN4 CLSTN1 CSTF2T CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PLOD3 PNKP PPIL1 PPL UBQLN2 WHRN
Entrez ID		11284	1308
HPRD ID		09284	00223
Ensembl ID		ENSG00000039650	ENSG00000065618
Uniprot IDs		Q96T60	Q9UMD9
PDB IDs		2BRF 2W3O
Enriched GO Terms of Interacting Partners?
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