TRPC4 and ITPR2

Number of citations of the paper that reports this interaction (PubMedID 11163362)
17

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		TRPC4	ITPR2
Description		transient receptor potential cation channel subfamily C member 4	inositol 1,4,5-trisphosphate receptor type 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell-cell Junction Cell Surface Basolateral Plasma Membrane Cortical Cytoskeleton Cation Channel Complex Calcium Channel Complex	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Cortex Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Cytoplasmic Vesicle Membrane Secretory Granule Membrane Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Receptor Complex
	Molecular Function	Calcium Channel Activity Protein Binding Beta-catenin Binding Store-operated Calcium Channel Activity Cadherin Binding Inositol 1,4,5 Trisphosphate Binding	Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Binding Calcium Ion Transmembrane Transporter Activity Phosphatidylinositol Binding Transmembrane Transporter Binding Inositol 1,4,5 Trisphosphate Binding Scaffold Protein Binding
	Biological Process	Calcium Ion Transport Manganese Ion Transport Gamma-aminobutyric Acid Secretion Oligodendrocyte Differentiation Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Import Calcium Ion Transmembrane Transport	Response To Hypoxia Signal Transduction Inositol Phosphate-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To CAMP Cellular Response To Ethanol
Pathways		TRP channels Role of second messengers in netrin-1 signaling	PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Caffeine
Diseases
GWAS		Age-related macular degeneration ( 23326517) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Mild influenza (H1N1) infection ( 26379185) Obesity-related traits ( 23251661) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Alanine aminotransferase levels ( 33547301) Amyotrophic lateral sclerosis ( 17827064) Birth weight ( 31043758 27680694) Body shape index ( 34021172) BRCA1/2-negative high-risk breast cancer ( 30323354) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Kashin-Beck disease ( 25303641) LDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte counts ( 32888494) Major depressive disorder ( 27479909) Male-pattern baldness ( 27182965) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Refractive error ( 32231278) Renal cell carcinoma ( 31231134 22010048) Retinitis pigmentosa ( 33514863) Serum alkaline phosphatase levels ( 33547301) Smooth-surface caries ( 24556642) Type 2 diabetes ( 30054458 30297969) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		10 interacting genes: DRD2 ITCH ITPR1 ITPR2 ITPR3 MX1 SLC9A3R1 TJP1 TRPC1 TRPC5	6 interacting genes: BANK1 LINC01554 PKP2 PRKACA TRPC1 TRPC4
Entrez ID		7223	3709
HPRD ID		09154	02536
Ensembl ID		ENSG00000133107	ENSG00000123104
Uniprot IDs		Q9UBN4	Q14571
PDB IDs
Enriched GO Terms of Interacting Partners?
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