TRPC4 and ITPR3

Number of citations of the paper that reports this interaction (PubMedID 11290752)
84

Data Source:
HPRD (two hybrid, in vitro)

		TRPC4	ITPR3
Description		transient receptor potential cation channel subfamily C member 4	inositol 1,4,5-trisphosphate receptor type 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell-cell Junction Cell Surface Basolateral Plasma Membrane Cortical Cytoskeleton Cation Channel Complex Calcium Channel Complex	Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane Sarcoplasmic Reticulum Cytoplasmic Vesicle Membrane Secretory Granule Membrane Platelet Dense Tubular Network Membrane Neuronal Cell Body Myelin Sheath Receptor Complex Apical Part Of Cell
	Molecular Function	Calcium Channel Activity Protein Binding Beta-catenin Binding Store-operated Calcium Channel Activity Cadherin Binding Inositol 1,4,5 Trisphosphate Binding	Inositol Hexakisphosphate Binding Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Binding Protein Binding Calcium-release Channel Activity Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Calcium Ion Transport Manganese Ion Transport Gamma-aminobutyric Acid Secretion Oligodendrocyte Differentiation Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Import Calcium Ion Transmembrane Transport	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Memory Inositol Phosphate-mediated Signaling Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Release Of Sequestered Calcium Ion Into Cytosol Response To Calcium Ion Long-term Synaptic Potentiation Calcium Ion Transport Into Cytosol
Pathways		TRP channels Role of second messengers in netrin-1 signaling	PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Caffeine
Diseases
GWAS		Age-related macular degeneration ( 23326517) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Mild influenza (H1N1) infection ( 26379185) Obesity-related traits ( 23251661) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma and attention deficit hyperactivity disorder ( 31619474) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 23850713) Educational attainment ( 23722424) Hodgkin's lymphoma ( 30194254) Multiple sclerosis and body mass index (pleiotropy) ( 26920376) Obesity (extreme) ( 19553259) Phosphorus levels ( 20558539) Regular attendance at a gym or sports club ( 29970889) Total carotid plaque area (excess vs minimal atherosclerosis) ( 32811377) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		10 interacting genes: DRD2 ITCH ITPR1 ITPR2 ITPR3 MX1 SLC9A3R1 TJP1 TRPC1 TRPC5	18 interacting genes: AKT1 ANK1 BAP1 BECN1 CABP1 ITPR1 MTDH MTNR1A MTNR1B SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2
Entrez ID		7223	3710
HPRD ID		09154	00926
Ensembl ID		ENSG00000133107	ENSG00000096433
Uniprot IDs		Q9UBN4	A6H8K3 Q14573 Q59ES2
PDB IDs			6DQJ 6DQN 6DQS 6DQV 6DQZ 6DR0 6DR2 6DRA 6DRC 6UQK
Enriched GO Terms of Interacting Partners?
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