ITPR2 and BANK1

Number of citations of the paper that reports this interaction (PubMedID 11782428)
68

Data Source:
HPRD (in vivo)

		ITPR2	BANK1
Description		inositol 1,4,5-trisphosphate receptor type 2	B cell scaffold protein with ankyrin repeats 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Cortex Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Cytoplasmic Vesicle Membrane Secretory Granule Membrane Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Receptor Complex	Perinuclear Region Of Cytoplasm
	Molecular Function	Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Binding Calcium Ion Transmembrane Transporter Activity Phosphatidylinositol Binding Transmembrane Transporter Binding Inositol 1,4,5 Trisphosphate Binding Scaffold Protein Binding	Protease Binding NAD+ Nucleosidase Activity Signaling Receptor Binding Protein Binding Signaling Adaptor Activity Phospholipase Binding Protein Tyrosine Kinase Binding
	Biological Process	Response To Hypoxia Signal Transduction Inositol Phosphate-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To CAMP Cellular Response To Ethanol	Response To Bacterium Negative Regulation Of Interleukin-6 Production B Cell Activation Positive Regulation Of MAPK Cascade Negative Regulation Of Translational Initiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Activation Negative Regulation Of Protein Kinase B Signaling
Pathways		PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Caffeine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Amyotrophic lateral sclerosis ( 17827064) Birth weight ( 31043758 27680694) Body shape index ( 34021172) BRCA1/2-negative high-risk breast cancer ( 30323354) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Kashin-Beck disease ( 25303641) LDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte counts ( 32888494) Major depressive disorder ( 27479909) Male-pattern baldness ( 27182965) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Refractive error ( 32231278) Renal cell carcinoma ( 31231134 22010048) Retinitis pigmentosa ( 33514863) Serum alkaline phosphatase levels ( 33547301) Smooth-surface caries ( 24556642) Type 2 diabetes ( 30054458 30297969) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Adventurousness ( 30643258) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alzheimer's disease ( 33654092) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 22763476) Blood protein levels ( 28240269) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 28165464 26956414) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 30224653) General cognitive ability ( 29844566) ghrelin levels ( 33852427) Gut microbiota (beta diversity) ( 27723756) Hand grip strength ( 29691431) Hypertension ( 31879980) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Lupus nephritis in systemic lupus erythematosus ( 34127828) Mean platelet volume ( 32888494 27863252) Multisite chronic pain ( 33830993) Refractive error ( 32231278) Schizophrenia ( 29483656) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 27399966 18204447 23273568 33272962 26502338 28714469) Systolic blood pressure ( 30578418)
Interacting Genes		6 interacting genes: BANK1 LINC01554 PKP2 PRKACA TRPC1 TRPC4	4 interacting genes: ITPR1 ITPR2 LYN TRAF6
Entrez ID		3709	55024
HPRD ID		02536	09819
Ensembl ID		ENSG00000123104	ENSG00000153064
Uniprot IDs		Q14571	Q8NDB2
PDB IDs
Enriched GO Terms of Interacting Partners?
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