TRPC1 and TRPC4

Number of citations of the paper that reports this interaction (PubMedID 12032305)
231

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfer)
HPRD (in vivo)

		TRPC1	TRPC4
Description		transient receptor potential cation channel subfamily C member 1	transient receptor potential cation channel subfamily C member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cation Channel Complex Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell-cell Junction Cell Surface Basolateral Plasma Membrane Cortical Cytoskeleton Cation Channel Complex Calcium Channel Complex
	Molecular Function	Signaling Receptor Binding Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity ATPase Binding Inositol 1,4,5 Trisphosphate Binding	Calcium Channel Activity Protein Binding Beta-catenin Binding Store-operated Calcium Channel Activity Cadherin Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Calcium Ion Transport Manganese Ion Transport Melanin Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Calcium Ion Transmembrane Transport Regulation Of Cardiac Conduction	Calcium Ion Transport Manganese Ion Transport Gamma-aminobutyric Acid Secretion Oligodendrocyte Differentiation Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Import Calcium Ion Transmembrane Transport
Pathways		TRP channels Role of second messengers in netrin-1 signaling Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23326517) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Mild influenza (H1N1) infection ( 26379185) Obesity-related traits ( 23251661) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		14 interacting genes: BMPR2 CAV1 GRIA1 HOMER1 HOMER3 ITPR2 ITPR3 MDFI MX1 PKD2 RHOA TRPC3 TRPC4 TRPC5	10 interacting genes: DRD2 ITCH ITPR1 ITPR2 ITPR3 MX1 SLC9A3R1 TJP1 TRPC1 TRPC5
Entrez ID		7220	7223
HPRD ID		11894	09154
Ensembl ID		ENSG00000144935	ENSG00000133107
Uniprot IDs		P48995	Q9UBN4
PDB IDs
Enriched GO Terms of Interacting Partners?
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