ACTC1 and ACTN4

Number of citations of the paper that reports this interaction (PubMedID 12042308)
42

Data Source:
HPRD (in vivo)

		ACTC1	ACTN4
Description		actin alpha cardiac muscle 1	actinin alpha 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Dynactin Complex Actin Filament Focal Adhesion Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Extracellular Exosome Blood Microparticle	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Nuclear Body Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Microfilament Motor Activity ATP Binding Myosin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Transmembrane Transporter Binding Actin Filament Binding
	Biological Process	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration	Protein Transport Actin Cytoskeleton Organization Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cellular Component Movement Muscle Cell Development Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Nucleic Acid-templated Transcription
Pathways		Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle	Platelet degranulation Nephrin family interactions
Drugs
Diseases
GWAS		Axial length ( 24144296) Refractive error ( 32231278 20835239)	Brain morphology (MOSTest) ( 32665545) Fasting glucose ( 34074324) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)
Interacting Genes		42 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1	55 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 DDIAS ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR
Entrez ID		70	81
HPRD ID		00015	05222
Ensembl ID		ENSG00000159251	ENSG00000130402
Uniprot IDs		B3KPP5 P68032	A0A0S2Z3G9 F5GXS2 H7C144 O43707
PDB IDs			1WLX 1YDI 2R0O 6O31 6OA6
Enriched GO Terms of Interacting Partners?
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