ACTC1 and AFAP1

Number of citations of the paper that reports this interaction (PubMedID 12134071)
17

Data Source:
HPRD (in vivo)

		ACTC1	AFAP1
Description		actin alpha cardiac muscle 1	actin filament associated protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Dynactin Complex Actin Filament Focal Adhesion Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Extracellular Exosome Blood Microparticle	Cytosol Focal Adhesion Actin Cytoskeleton
	Molecular Function	Microfilament Motor Activity ATP Binding Myosin Binding	Actin Binding SH3 Domain Binding SH2 Domain Binding
	Biological Process	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration	Regulation Of Signal Transduction Regulation Of Cytoskeleton Organization
Pathways		Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle
Drugs
Diseases
GWAS		Axial length ( 24144296) Refractive error ( 32231278 20835239)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cadmium levels ( 26025379) Cortical surface area (MOSTest) ( 32665545) Diverticular disease ( 30177863) Glaucoma ( 30104761 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935 25173105 27623284 29452408 25861811) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Intraocular pressure ( 29617998 29785010 31959993 30054594 29235454) Lung function (FEV1/FVC) ( 30061609 30804560) Medication use (antiglaucoma preparations and miotics) ( 31015401) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulse pressure ( 27618447) Response to antidepressants (symptom improvement) ( 29160301) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		42 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1	9 interacting genes: ACTA1 ACTC1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ SRC
Entrez ID		70	60312
HPRD ID		00015	09747
Ensembl ID		ENSG00000159251	ENSG00000196526
Uniprot IDs		B3KPP5 P68032	Q6ZRV0 Q8N556
PDB IDs
Enriched GO Terms of Interacting Partners?
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