STK3 and SULT2A1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		STK3	SULT2A1
Description		serine/threonine kinase 3	sulfotransferase family 2A member 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Cytoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity	Alcohol Sulfotransferase Activity Protein Binding Sulfotransferase Activity Bile-salt Sulfotransferase Activity Steroid Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding
	Biological Process	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Protein Tetramerization Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Ethanol Catabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Catabolic Process Bile Acid Catabolic Process Thyroid Hormone Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation
Pathways		Signaling by Hippo	Cytosolic sulfonation of small molecules PPARA activates gene expression
Drugs		Fostamatinib	Adenosine 3',5'-diphosphate Aetiocholanolone Mercuric iodide
Diseases
GWAS		Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)	Apolipoprotein A1 levels ( 32203549) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels ( 30072576) Cleft palate ( 30452639) Dehydroepiandrosterone sulphate levels ( 21533175) Estradiol levels ( 34255042) Gallstone disease ( 30504769 27094239) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum metabolite levels ( 33031748 23093944) Sex hormone levels ( 26014426) Triglyceride levels ( 32203549) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		42 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GABARAP GABARAPL1 GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS1 LATS2 LRRK2 MAP1LC3B MAP1LC3C MARK2 MBP MOB1B MOB3B MOB4 MPP1 OGT ORM2 PEX19 PHAX PLK1 QARS1 RAF1 RASSF4 SAV1 SLMAP SNIP1 SULT2A1 TFPT TRAF1 ZC3H7A	8 interacting genes: DPYD GDF15 NIF3L1 PRDX4 STAT3 STK3 SULT1B1 TMX1
Entrez ID		6788	6822
HPRD ID		05433	00502
Ensembl ID		ENSG00000104375	ENSG00000105398
Uniprot IDs		A0A087WZ06 A0A384MR07 Q13188	A8K015 Q06520
PDB IDs		3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2	1EFH 1J99 1OV4 2QP3 2QP4 3F3Y 4IFB
Enriched GO Terms of Interacting Partners?
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