STK3 and GABARAP

Number of citations of the paper that reports this interaction (PubMedID 31857374)
10

Data Source:
BioGRID (pull down, pull down)

		STK3	GABARAP
Description		serine/threonine kinase 3	GABA type A receptor-associated protein
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Golgi Membrane Autophagosome Membrane Lysosome Autophagosome Smooth Endoplasmic Reticulum Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Actin Cytoskeleton Cytoplasmic Vesicle Cell Body Synapse Perinuclear Region Of Cytoplasm Sperm Midpiece
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity	Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding
	Biological Process	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Protein Tetramerization Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Autophagosome Assembly Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Protein Targeting Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Macroautophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Rac Protein Signal Transduction Positive Regulation Of Protein K48-linked Ubiquitination
Pathways		Signaling by Hippo	Macroautophagy TBC/RABGAPs
Drugs		Fostamatinib
Diseases
GWAS		Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)	Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		42 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GABARAP GABARAPL1 GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS1 LATS2 LRRK2 MAP1LC3B MAP1LC3C MARK2 MBP MOB1B MOB3B MOB4 MPP1 OGT ORM2 PEX19 PHAX PLK1 QARS1 RAF1 RASSF4 SAV1 SLMAP SNIP1 SULT2A1 TFPT TRAF1 ZC3H7A	61 interacting genes: AMBRA1 ANK2 ANK3 ATG101 ATG13 ATG3 ATG4A ATG4B ATG4C ATG4D ATG7 ATXN3 BIRC6 CUL3 DMPK DVL2 FLCN GABRG1 GABRG2 GABRG3 GJA1 GPHN HDAC5 KBTBD7 KDR LMNB1 MAPK15 MEFV MIB1 MLH1 MPC1 MYBPC2 NBR1 NEDD4 NEK9 NSF OPTN PCM1 PGS1 PKP4 PRKCZ RB1CC1 SEC62 SNX18 SQSTM1 SRPK1 SRPK2 STK3 TAX1BP1 TBC1D25 TFRC TLE5 TP53INP1 TRIM21 TRIM32 TSR2 TTN TUBB3 ULK1 ULK2 VPS28
Entrez ID		6788	11337
HPRD ID		05433	05496
Ensembl ID		ENSG00000104375	ENSG00000170296
Uniprot IDs		A0A087WZ06 A0A384MR07 Q13188	O95166 Q6IAW1
PDB IDs		3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2	1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO 7BRQ 7BRT 7BRU 7BV4
Enriched GO Terms of Interacting Partners?
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