STK3 and HSPE1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		STK3	HSPE1
Description		serine/threonine kinase 3	heat shock protein family E (Hsp10) member 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity	RNA Binding Protein Binding ATP Binding Metal Ion Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Protein Tetramerization Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Osteoblast Differentiation Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Chaperone Cofactor-dependent Protein Refolding
Pathways		Signaling by Hippo	RHOG GTPase cycle
Drugs		Fostamatinib	Phenethyl Isothiocyanate
Diseases
GWAS		Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Schizophrenia ( 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		42 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GABARAP GABARAPL1 GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS1 LATS2 LRRK2 MAP1LC3B MAP1LC3C MARK2 MBP MOB1B MOB3B MOB4 MPP1 OGT ORM2 PEX19 PHAX PLK1 QARS1 RAF1 RASSF4 SAV1 SLMAP SNIP1 SULT2A1 TFPT TRAF1 ZC3H7A	16 interacting genes: ALDH2 APLP1 CASP3 CRMP1 EEF1A1 ERG28 GBP2 HSPD1 LRIF1 NTAQ1 SAT1 SELENOM STK3 TLE1 UNC119 ZHX1
Entrez ID		6788	3336
HPRD ID		05433	02535
Ensembl ID		ENSG00000104375	ENSG00000115541
Uniprot IDs		A0A087WZ06 A0A384MR07 Q13188	A0A384N6A4 P61604
PDB IDs		3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2	4PJ1 6HT7 6MRC 6MRD
Enriched GO Terms of Interacting Partners?
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