PSEN1 and RYR2

  • Number of citations of the paper that reports this interaction (PubMedID 24029002)
  • 11

PSEN1

RYR2

Description presenilin 1 ryanodine receptor 2
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GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Acute lymphoblastic leukemia (childhood) ( 19684603)
  • Bipolar disorder and eating disorder ( 26433762)
  • Cerivastatin-induced rhabdomyolysis ( 21386754)
  • cognitive impairment (MMSE score) in Parkinson’s disease ( 33613413)
  • Exercise treadmill test traits ( 17903301)
  • General risk tolerance (MTAG) ( 30643258)
  • Hippocampal volume ( 31530798)
  • Hypertension ( 17554300)
  • Lipid traits ( 30576415 24386095)
  • Lung function (FEV1) ( 30061609)
  • Lung function (FVC) ( 30061609)
  • Metabolite levels ( 23823483)
  • Obesity-related traits ( 23251661)
  • Postoperative stroke after cardiac surgery ( 30678657)
  • PR interval ( 32439900)
  • Response to taxane treatment (docetaxel) ( 23006423)
  • Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes 98 interacting genes: ACTN1 AP1M2 APBA1 APH1A APH1B APOE APP BACE1 BCL2 BCL2L1 CASP1 CASP3 CASP4 CASP6 CASP7 CASP8 CDH1 CDK5 CFL1 CIB1 CKB CTNNA1 CTNNB1 CTNND1 CTNND2 CYP2C18 CYP2C8 DCT DLL1 DOCK3 ECSIT EFHD1 EFNB2 ENSA EPB41L3 ERN1 ETFA FBXL12 FBXW7 FGF13 FLNA FLNB GAPDH GCDH GDI1 GFAP GSK3B GSTZ1 HERPUD1 HMGB1 ICAM5 ITSN2 JUP KANK2 KCNIP3 KCNIP4 LRRC74A MAPK9 MAPT METTL2B MTCH1 NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OXCT1 PDCD4 PIK3R1 PKP4 PRAM1 PRDX2 PRKACA PRKCZ PSENEN PSMA5 PSMB1 RAB11A RAB3A RAD23A RBSN RHEB RMDN3 RNF32 RYR2 SCAF11 SCN1A SLC10A6 SNUPN ST13 STAMBPL1 TCF7L2 TDP2 TUBA1B UBQLN1 UMPS YME1L1 16 interacting genes: AKAP6 ALB CACNA1C FKBP1B HOMER1 HSPB2 ITPR1 LINC00839 MDM2 PRKACA PRKAR2A PSEN1 RYR1 RYR3 SMAD5 SRI
Entrez ID 5663 6262
HPRD ID 00087 01619
Ensembl ID ENSG00000080815 ENSG00000198626
Uniprot IDs A0A024R6A3 A0A0S2Z4D2 P49768 Q92736
PDB IDs 2KR6 4UIS 5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X 4JKQ 6Y4O 6Y4P
Enriched GO Terms of Interacting Partners?
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