PSEN1 and CYP2C18

  • Number of citations of the paper that reports this interaction (PubMedID 21163940)
  • 36
  • Data Source:
  • BioGRID (two hybrid)

PSEN1

CYP2C18

Description presenilin 1 cytochrome P450 family 2 subfamily C member 18
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GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Acenocoumarol maintenance dosage ( 19578179)
  • Clopidogrel active metabolite levels ( 28207573)
  • Common carotid intima-media thickness in HIV negative individuals ( 29206233)
  • Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)
  • Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102)
  • Red cell distribution width ( 32888494)
  • Response to clopidogrel therapy ( 28207573 19706858)
  • Serum alkaline phosphatase levels ( 33547301)
  • Serum metabolite levels ( 23093944)
  • Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122)
  • Warfarin maintenance dose ( 23755828)
  • Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes 98 interacting genes: ACTN1 AP1M2 APBA1 APH1A APH1B APOE APP BACE1 BCL2 BCL2L1 CASP1 CASP3 CASP4 CASP6 CASP7 CASP8 CDH1 CDK5 CFL1 CIB1 CKB CTNNA1 CTNNB1 CTNND1 CTNND2 CYP2C18 CYP2C8 DCT DLL1 DOCK3 ECSIT EFHD1 EFNB2 ENSA EPB41L3 ERN1 ETFA FBXL12 FBXW7 FGF13 FLNA FLNB GAPDH GCDH GDI1 GFAP GSK3B GSTZ1 HERPUD1 HMGB1 ICAM5 ITSN2 JUP KANK2 KCNIP3 KCNIP4 LRRC74A MAPK9 MAPT METTL2B MTCH1 NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OXCT1 PDCD4 PIK3R1 PKP4 PRAM1 PRDX2 PRKACA PRKCZ PSENEN PSMA5 PSMB1 RAB11A RAB3A RAD23A RBSN RHEB RMDN3 RNF32 RYR2 SCAF11 SCN1A SLC10A6 SNUPN ST13 STAMBPL1 TCF7L2 TDP2 TUBA1B UBQLN1 UMPS YME1L1 6 interacting genes: A2M APOE ECSIT KMT2E PSEN1 SDC2
Entrez ID 5663 1562
HPRD ID 00087 03085
Ensembl ID ENSG00000080815 ENSG00000108242
Uniprot IDs A0A024R6A3 A0A0S2Z4D2 P49768 P33260 Q7Z348
PDB IDs 2KR6 4UIS 5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC 6LQG 6LR4 7C9I 7D8X 2CIK 2H6P
Enriched GO Terms of Interacting Partners?
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