EMC3 and MTAP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		EMC3	MTAP
Description		ER membrane protein complex subunit 3	methylthioadenosine phosphorylase
Image
GO Annotations	Cellular Component	Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane EMC Complex	Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Membrane Insertase Activity	1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding S-methyl-5-thioadenosine Phosphorylase Activity
	Biological Process	Protein Insertion Into ER Membrane By Stop-transfer Membrane-anchor Sequence Tail-anchored Membrane Protein Insertion Into ER Membrane	Nucleobase-containing Compound Metabolic Process Purine Ribonucleoside Salvage Nicotinamide Riboside Catabolic Process L-methionine Salvage From Methylthioadenosine Methylation Response To Testosterone
Pathways		RHOA GTPase cycle	Methionine salvage pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Adenine (2S,3S,4R,5S)-2-(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(methylsulfanyl)methyl]-3,4-pyrrolidinediol Formycin 5'-S-methyl-5'-thioadenosine 5'-Deoxy-5'-(Methylthio)-Tubercidin
Diseases
GWAS			Adverse response to drug ( 30420678) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary heart disease ( 21606135) Cutaneous malignant melanoma ( 32341527) Cutaneous nevi ( 19578365) Diastolic blood pressure ( 28135244) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Glycated hemoglobin levels ( 28898252) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Macular thickness ( 30535121) Mean spheric corpuscular volume ( 32888494) Melanoma ( 21983787 28212542) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Pediatric bone mineral content (radius) ( 26041818) Pulse pressure ( 28135244)
Interacting Genes		1 interacting genes: MTAP	9 interacting genes: CDC25A CENPH EMC3 FOLH1 LYRM1 MYLIP PKD2 PLCB2 RELB
Entrez ID		55831	4507
HPRD ID		17426	01134
Ensembl ID		ENSG00000125037	ENSG00000099810
Uniprot IDs		Q9P0I2	A0A384ME80 Q13126
PDB IDs		6WW7 6Z3W 7ADO 7ADP	1CB0 1CG6 1K27 1SD1 1SD2 3LN5 3OZC 3OZD 3OZE 5EUB 5TC5 5TC6 5TC7 5TC8 6DYZ 6DZ0 6DZ2 6DZ3
Enriched GO Terms of Interacting Partners?
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