RNF130 and UBE2Z

Number of citations of the paper that reports this interaction (PubMedID 19690564)
64

Data Source:
BioGRID (two hybrid)

		RNF130	UBE2Z
Description		ring finger protein 130	ubiquitin conjugating enzyme E2 Z
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Integral Component Of Membrane	Nucleus Nucleoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Programmed Cell Death Protein Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		LDL cholesterol ( 21347282) Pre-treatment viral load in HIV-1 infection ( 31219150) Systolic blood pressure ( 30224653)	Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 26343387) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 30054458 29358691)
Interacting Genes		13 interacting genes: ARPC4 FGFR3 SCN2A TGFBR1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2Z	39 interacting genes: AK8 BMPR1B CCT3 DZIP3 GORASP2 HLTF HMBOX1 INCA1 LNX2 LPL MDM2 OTUB1 PLEKHA6 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM3 TRIM46 TRIM65 UBA1 UBA6 UBD
Entrez ID		55819	65264
HPRD ID		11504	08589
Ensembl ID		ENSG00000113269	ENSG00000159202
Uniprot IDs		E5RI87 Q2HIY3 Q86XS8	Q9H832
PDB IDs			5A4P
Enriched GO Terms of Interacting Partners?
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