RNF130 and SCN2A

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		RNF130	SCN2A
Description		ring finger protein 130	sodium voltage-gated channel alpha subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Integral Component Of Membrane	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Membrane T-tubule Axon Intrinsic Component Of Plasma Membrane Node Of Ranvier Paranode Region Of Axon Sodium Channel Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Programmed Cell Death Protein Ubiquitination	Sodium Ion Transport Nervous System Development Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Cellular Response To Hypoxia Membrane Depolarization During Action Potential
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Tramadol Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Metergoline Bioallethrin Amylmetacresol Fish oil
Diseases
GWAS		LDL cholesterol ( 21347282) Pre-treatment viral load in HIV-1 infection ( 31219150) Systolic blood pressure ( 30224653)	Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Bipolar disorder ( 33263727 31043756) Diastolic blood pressure ( 30224653) Epilepsy ( 30531953) Factor VII activity ( 30642921) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Trunk fat mass ( 28552196) Urinary sodium excretion ( 31409800)
Interacting Genes		13 interacting genes: ARPC4 FGFR3 SCN2A TGFBR1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2Z	10 interacting genes: ANK3 ARHGEF10L B4GAT1 BAZ2B GALNT13 MPP3 PKP4 PLA2R1 RNF130 SCN4B
Entrez ID		55819	6326
HPRD ID		11504	03133
Ensembl ID		ENSG00000113269	ENSG00000136531
Uniprot IDs		E5RI87 Q2HIY3 Q86XS8	Q99250
PDB IDs			2KAV 4JPZ 4RLY 6BUT 6J8E
Enriched GO Terms of Interacting Partners?
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