UBE2Z and TRIM65

Number of citations of the paper that reports this interaction (PubMedID 19549727)
74

Data Source:
BioGRID (two hybrid)

		UBE2Z	TRIM65
Description		ubiquitin conjugating enzyme E2 Z	tripartite motif containing 65
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleoplasm Cytosol
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Zinc Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process	Positive Regulation Of Autophagy
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 26343387) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 30054458 29358691)	Body mass index ( 29273807) Deep white matter hyperintensities ( 32517579) Psoriasis ( 28537254) Reticulocyte count ( 32888494) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 21681796 25663218) White matter hyperintensity volume ( 30659137 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		39 interacting genes: AK8 BMPR1B CCT3 DZIP3 GORASP2 HLTF HMBOX1 INCA1 LNX2 LPL MDM2 OTUB1 PLEKHA6 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM3 TRIM46 TRIM65 UBA1 UBA6 UBD	14 interacting genes: ANAPC11 DDX58 IFIH1 MARCHF7 MKRN3 RBCK1 SRPK1 TNRC6A UBE2D2 UBE2N UBE2U UBE2Z UBE3A VCAM1
Entrez ID		65264	201292
HPRD ID		08589	15569
Ensembl ID		ENSG00000159202	ENSG00000141569
Uniprot IDs		Q9H832	Q6PJ69
PDB IDs		5A4P	7JL0 7JL2 7JL4
Enriched GO Terms of Interacting Partners?
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