UBE2Z and DZIP3

Number of citations of the paper that reports this interaction (PubMedID 19549727)
74

Data Source:
BioGRID (two hybrid)

		UBE2Z	DZIP3
Description		ubiquitin conjugating enzyme E2 Z	DAZ interacting zinc finger protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Phosphatase Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process	Protein Polyubiquitination
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 26343387) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 30054458 29358691)	Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		39 interacting genes: AK8 BMPR1B CCT3 DZIP3 GORASP2 HLTF HMBOX1 INCA1 LNX2 LPL MDM2 OTUB1 PLEKHA6 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM3 TRIM46 TRIM65 UBA1 UBA6 UBD	53 interacting genes: AKTIP AP1M1 ARHGAP32 ATXN1 BAG4 BIRC2 BIRC3 CARM1 CEP63 DAZ1 FBXO17 GRIP1 GTF2H2C_2 HNRNPF HNRNPH1 HNRNPUL1 HOTAIR HOXC8 MIR20A MIR29C NCOR1 PCGF3 PITX1 RAD18 RBM4B RNF38 RUNX1 TNFRSF18 TNS2 TOLLIP TRIM21 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2N UBE2R2 UBE2U UBE2V1 UBE2V2 UBE2W UBE2Z UBR3 ZCCHC10 ZNF24 ZNF765
Entrez ID		65264	9666
HPRD ID		08589	10562
Ensembl ID		ENSG00000159202	ENSG00000198919
Uniprot IDs		Q9H832	Q86Y13
PDB IDs		5A4P
Enriched GO Terms of Interacting Partners?
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