TMEM176A and CERS4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMEM176A	CERS4
Description		transmembrane protein 176A	ceramide synthase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Negative Regulation Of Dendritic Cell Differentiation	Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Height ( 20881960 23563607) Metabolite levels ( 23823483) Serum alkaline phosphatase levels ( 33547301) Serum metabolite concentrations in chronic kidney disease ( 29545352) Waist circumference adjusted for body mass index ( 34021172)	Macular telangiectasia type 2 ( 33654266) Mean reticulocyte volume ( 32888494) Metabolite levels ( 31628463) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingolipid levels ( 26068415) Sphingomyelin levels ( 31551469) Thyroid stimulating hormone levels ( 30367059 32769997) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)
Interacting Genes		17 interacting genes: CD79A CERS4 CHPF2 GOLM1 HIVEP1 KCNK5 MFSD14B MTIF3 RETREG3 RIDA SCD5 SGPL1 TGM2 TIMMDC1 TMEM176B TMX2 VKORC1	47 interacting genes: - C1QL4 CCL4L2 CLEC1A COL4A5 CTXN3 CXCL16 CYB5R3 EMD FATE1 FCER1G FXYD6 FXYD6-FXYD2 GPR151 IER3IP1 IGFBP5 ITGAM JAGN1 LHFPL5 MS4A1 NAT8 NEU1 PLP2 PNLIPRP1 PTPN9 SCAMP5 SCD SERF1A SERF1B SERP2 SLC13A4 SLC29A2 SLC35A1 SLC35F6 SLC7A1 SMIM11 STX7 STX8 TEX264 TMEM119 TMEM176A TMEM254 TMEM72 TOMM6 TSPO2 UPK1B VAMP2
Entrez ID		55365	79603
HPRD ID		13635	13962
Ensembl ID		ENSG00000002933	ENSG00000090661
Uniprot IDs		A0A090N8H6 Q96HP8	Q53HF9 Q9HA82
PDB IDs
Enriched GO Terms of Interacting Partners?
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