CERS4 and C1QL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CERS4	C1QL4
Description		ceramide synthase 4	complement C1q like 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Collagen Trimer Extracellular Space
	Molecular Function	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity	Protein Binding Identical Protein Binding
	Biological Process	Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process	Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Macular telangiectasia type 2 ( 33654266) Mean reticulocyte volume ( 32888494) Metabolite levels ( 31628463) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingolipid levels ( 26068415) Sphingomyelin levels ( 31551469) Thyroid stimulating hormone levels ( 30367059 32769997) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)
Interacting Genes		47 interacting genes: - C1QL4 CCL4L2 CLEC1A COL4A5 CTXN3 CXCL16 CYB5R3 EMD FATE1 FCER1G FXYD6 FXYD6-FXYD2 GPR151 IER3IP1 IGFBP5 ITGAM JAGN1 LHFPL5 MS4A1 NAT8 NEU1 PLP2 PNLIPRP1 PTPN9 SCAMP5 SCD SERF1A SERF1B SERP2 SLC13A4 SLC29A2 SLC35A1 SLC35F6 SLC7A1 SMIM11 STX7 STX8 TEX264 TMEM119 TMEM176A TMEM254 TMEM72 TOMM6 TSPO2 UPK1B VAMP2	19 interacting genes: CD53 CERS4 FATE1 FNDC9 GOLM1 GPR152 IL10RA LEUTX MFF RHCG SCARA5 SGTA SGTB SLC38A1 SSMEM1 TMEM179B TMPRSS2 TRHR UBQLN2
Entrez ID		79603	338761
HPRD ID		13962	17350
Ensembl ID		ENSG00000090661	ENSG00000186897
Uniprot IDs		Q53HF9 Q9HA82	A0A3B0INP7 Q86Z23
PDB IDs
Enriched GO Terms of Interacting Partners?
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