TMEM176A and KCNK5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TMEM176A	KCNK5
Description		transmembrane protein 176A	potassium two pore domain channel subfamily K member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding	Voltage-gated Ion Channel Activity Potassium Channel Activity Protein Binding Potassium Ion Leak Channel Activity
	Biological Process	Negative Regulation Of Dendritic Cell Differentiation	Potassium Ion Transport Excretion Stabilization Of Membrane Potential Regulation Of Ion Transmembrane Transport Regulation Of Resting Membrane Potential Potassium Ion Transmembrane Transport Potassium Ion Export Across Plasma Membrane
Pathways			Phase 4 - resting membrane potential
Drugs
Diseases
GWAS		Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Height ( 20881960 23563607) Metabolite levels ( 23823483) Serum alkaline phosphatase levels ( 33547301) Serum metabolite concentrations in chronic kidney disease ( 29545352) Waist circumference adjusted for body mass index ( 34021172)	Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Eating disorders ( 23568457) Fasting plasma glucose ( 32682390) HDL cholesterol levels ( 32203549) Hypertension in type 2 diabetes ( 33276381) Kidney stones ( 31729369) Migraine ( 27322543) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Social communication problems ( 24564958) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Urolithiasis ( 30975718)
Interacting Genes		17 interacting genes: CD79A CERS4 CHPF2 GOLM1 HIVEP1 KCNK5 MFSD14B MTIF3 RETREG3 RIDA SCD5 SGPL1 TGM2 TIMMDC1 TMEM176B TMX2 VKORC1	30 interacting genes: ADIPOQ AGTRAP APP AQP1 ATP5PF BNIP2 CMTM5 COMT CYB5B FRAT1 GJB2 IGFBP5 LHFPL5 MAN2B2 ORMDL3 SLC66A2 SMCO4 STRIT1 TM4SF4 TMEM128 TMEM14A TMEM176A TMEM218 TMEM54 TMEM60 TNFRSF10C TSPAN33 VAMP3 YIF1A YIPF6
Entrez ID		55365	8645
HPRD ID		13635	04604
Ensembl ID		ENSG00000002933	ENSG00000164626
Uniprot IDs		A0A090N8H6 Q96HP8	A0A024RD32 A0A0B6VPR3 O95279
PDB IDs
Enriched GO Terms of Interacting Partners?
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