RIF1 and GNE

Number of citations of the paper that reports this interaction (PubMedID 17118363)
13

Data Source:
HPRD (two hybrid)

		RIF1	GNE
Description		replication timing regulatory factor 1	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Condensed Chromosome Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Cytoplasm Plasma Membrane Nuclear Body Nuclear Membrane Site Of Double-strand Break Spindle Midzone	Cytoplasm Cytosol
	Molecular Function	Protein Binding	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding ATP Binding UDP-N-acetylglucosamine 2-epimerase Activity N-acylmannosamine Kinase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Stem Cell Population Maintenance Telomere Maintenance In Response To DNA Damage Positive Regulation Of Isotype Switching Positive Regulation Of Histone H3-K9 Methylation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine Metabolic Process N-acetylneuraminate Metabolic Process Cell Adhesion Carbohydrate Phosphorylation
Pathways		Nonhomologous End-Joining (NHEJ)	Sialic acid metabolism Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2
Drugs
Diseases
GWAS		Lung cancer ( 23143601) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)
Interacting Genes		20 interacting genes: BRD7 CEP126 CHD3 DEFB1 FEZ1 GIT1 GNE GRB2 HAP1 LINC00839 NSG2 PABPC4 PIAS4 POT1 PPP1CA PPP1CC SETDB1 SMARCD1 SUMO2 TERF2IP	66 interacting genes: ADAMTSL4 C22orf39 CFP CRMP1 CYSRT1 ECM1 EGFL7 GRN GTPBP3 HOXA1 KIAA1549 KPRP KRT31 KRT34 KRT40 KRT83 KRT85 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MGAT5B NBPF19 NID2 NOTCH2NLA PLA2G10 PRICKLE4 RIF1 SIGMAR1 SPRY1 SPRY2 SPRY3 SSC4D TRIM27 TRIM42 TRIP6 TSPAN4 VWC2 WDR83 WWOX ZBTB16
Entrez ID		55183	10020
HPRD ID		10603	04825
Ensembl ID		ENSG00000080345	ENSG00000159921
Uniprot IDs		Q5UIP0	Q9Y223
PDB IDs			2YHW 2YHY 2YI1 3EO3 4ZHT
Enriched GO Terms of Interacting Partners?
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