GNE and CFP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GNE	CFP
Description		glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	complement factor properdin
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Specific Granule Lumen Collagen-containing Extracellular Matrix Tertiary Granule Lumen
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding ATP Binding UDP-N-acetylglucosamine 2-epimerase Activity N-acylmannosamine Kinase Activity Metal Ion Binding	Protein Binding
	Biological Process	N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine Metabolic Process N-acetylneuraminate Metabolic Process Cell Adhesion Carbohydrate Phosphorylation	Immune Response Complement Activation, Alternative Pathway Defense Response To Bacterium
Pathways		Sialic acid metabolism Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2	Alternative complement activation Activation of C3 and C5 Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins Neutrophil degranulation Regulation of Complement cascade
Drugs
Diseases
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)
Interacting Genes		66 interacting genes: ADAMTSL4 C22orf39 CFP CRMP1 CYSRT1 ECM1 EGFL7 GRN GTPBP3 HOXA1 KIAA1549 KPRP KRT31 KRT34 KRT40 KRT83 KRT85 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MGAT5B NBPF19 NID2 NOTCH2NLA PLA2G10 PRICKLE4 RIF1 SIGMAR1 SPRY1 SPRY2 SPRY3 SSC4D TRIM27 TRIM42 TRIP6 TSPAN4 VWC2 WDR83 WWOX ZBTB16	33 interacting genes: BANF2 C3 CFAP206 CFB CYSRT1 ETS1 FHL5 FKBP6 GEMIN4 GNE HEXIM2 HOXA1 KCTD9 KLHL38 KRTAP11-1 KRTAP12-2 KRTAP3-1 KRTAP6-2 LCE1A LONRF1 MID2 MTOR NEK6 NOXA1 PRKAB2 RECK SMARCC1 SPAG8 STK16 TRIP13 VENTX ZNF330 ZNF414
Entrez ID		10020	5199
HPRD ID		04825	02308
Ensembl ID		ENSG00000159921	ENSG00000126759
Uniprot IDs		Q9Y223	A0A0S2Z4I5 P27918
PDB IDs		2YHW 2YHY 2YI1 3EO3 4ZHT	1W0R 1W0S 6RUR 6RUS 6RUV 6RV6 6S08 6S0A 6S0B 6SEJ
Enriched GO Terms of Interacting Partners?
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