GNE and C22orf39

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GNE	C22orf39
Description		glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	chromosome 22 open reading frame 39
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding ATP Binding UDP-N-acetylglucosamine 2-epimerase Activity N-acylmannosamine Kinase Activity Metal Ion Binding	Protein Binding
	Biological Process	N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine Metabolic Process N-acetylneuraminate Metabolic Process Cell Adhesion Carbohydrate Phosphorylation
Pathways		Sialic acid metabolism Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2
Drugs
Diseases
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)
Interacting Genes		66 interacting genes: ADAMTSL4 C22orf39 CFP CRMP1 CYSRT1 ECM1 EGFL7 GRN GTPBP3 HOXA1 KIAA1549 KPRP KRT31 KRT34 KRT40 KRT83 KRT85 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MGAT5B NBPF19 NID2 NOTCH2NLA PLA2G10 PRICKLE4 RIF1 SIGMAR1 SPRY1 SPRY2 SPRY3 SSC4D TRIM27 TRIM42 TRIP6 TSPAN4 VWC2 WDR83 WWOX ZBTB16	42 interacting genes: ANKS1A BANP CABP2 CEP76 COL8A1 CRYBA2 CYSRT1 DTX2 EXOSC8 FRS3 GNE GRN HSD3B7 ID2 ID3 INCA1 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP13-2 KRTAP9-2 MAGEA11 MAPK8IP2 MDFI MGAT5B NFATC2IP PCSK5 PFDN5 PLSCR3 PPP2CB PSMA1 RBPMS RECK RIMBP3C SNX32 SYCE1L TRIB3 VWC2L ZNF620
Entrez ID		10020	128977
HPRD ID		04825	14041
Ensembl ID		ENSG00000159921	ENSG00000242259
Uniprot IDs		Q9Y223	Q6P5X5
PDB IDs		2YHW 2YHY 2YI1 3EO3 4ZHT
Enriched GO Terms of Interacting Partners?
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