SMG8 and MKS1

		SMG8	MKS1
Description		SMG8 nonsense mediated mRNA decay factor	MKS transition zone complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol	Cytoplasm Centrosome Centriole Cytosol Membrane MKS Complex Ciliary Basal Body
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Protein Kinase Activity	Neural Tube Closure Smoothened Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Determination Of Left/right Symmetry Epithelial Structure Maintenance Embryonic Digit Morphogenesis Motile Cilium Assembly Embryonic Skeletal System Development Branching Morphogenesis Of An Epithelial Tube Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Head Development Cardiac Septum Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Common Bile Duct Development Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Non-motile Cilium Assembly Embryonic Brain Development Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Hedgehog 'off' state Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS			Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		3 interacting genes: MKS1 PDZD11 SMG1	7 interacting genes: ABCC3 CACNA1G DDX24 DGKE RNF43 SMG8 TMEM67
Entrez ID		55181	54903
HPRD ID		08551	07900
Ensembl ID		ENSG00000167447	ENSG00000011143
Uniprot IDs		Q8ND04	A0A0S2Z5Z2 A0A7I2V2M0 B4DVC5 H0Y2S2 J3KSC6 Q9NXB0
PDB IDs		6L54 6SYT 6Z3R
Enriched GO Terms of Interacting Partners?
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