MKS1 and SMG8

		MKS1	SMG8
Description		MKS transition zone complex subunit 1	SMG8 nonsense mediated mRNA decay factor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Cytosol Membrane MKS Complex Ciliary Basal Body	Cellular_component Cytosol
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Neural Tube Closure Smoothened Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Determination Of Left/right Symmetry Epithelial Structure Maintenance Embryonic Digit Morphogenesis Motile Cilium Assembly Embryonic Skeletal System Development Branching Morphogenesis Of An Epithelial Tube Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Head Development Cardiac Septum Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Common Bile Duct Development Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Non-motile Cilium Assembly Embryonic Brain Development Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Protein Kinase Activity
Pathways		Hedgehog 'off' state Anchoring of the basal body to the plasma membrane	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		7 interacting genes: ABCC3 CACNA1G DDX24 DGKE RNF43 SMG8 TMEM67	3 interacting genes: MKS1 PDZD11 SMG1
Entrez ID		54903	55181
HPRD ID		07900	08551
Ensembl ID		ENSG00000011143	ENSG00000167447
Uniprot IDs		A0A0S2Z5Z2 A0A7I2V2M0 B4DVC5 H0Y2S2 J3KSC6 Q9NXB0	Q8ND04
PDB IDs			6L54 6SYT 6Z3R
Enriched GO Terms of Interacting Partners?
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