MTPAP and MAP3K8

		MTPAP	MAP3K8
Description		mitochondrial poly(A) polymerase	mitogen-activated protein kinase kinase kinase 8
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Intracellular Membrane-bounded Organelle	Cytosol
	Molecular Function	Magnesium Ion Binding UTP Binding RNA Binding Polynucleotide Adenylyltransferase Activity Protein Binding ATP Binding Nucleotidyltransferase Activity Manganese Ion Binding Identical Protein Binding Protein Homodimerization Activity RNA Adenylyltransferase Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	MRNA Polyadenylation RNA 3'-end Processing Histone MRNA Catabolic Process	MAPK Cascade Protein Phosphorylation Cell Cycle T Cell Costimulation
Pathways			CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Paclitaxel disposition in epithelial ovarian cancer ( 29367611)	Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)
Interacting Genes		4 interacting genes: AZI2 CALCOCO2 MAP3K8 TBK1	26 interacting genes: ACP6 ACY3 ADAM10 AKT1 BMPR2 CD40 CHUK GAD2 JCAD LYZL2 MAP2K1 MAP2K4 MAP3K14 MTPAP NFKB1 NFKB2 PARD3 PDK2 RANGAP1 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		55149	1326
HPRD ID		15097	01863
Ensembl ID		ENSG00000107951	ENSG00000107968
Uniprot IDs		Q9NVV4	P41279 Q6FG25
PDB IDs		3PQ1	4Y83 4Y85 5IU2
Enriched GO Terms of Interacting Partners?
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