RASIP1 and RAP2A

Number of citations of the paper that reports this interaction (PubMedID 15031288)
33

Data Source:
HPRD (two hybrid)

		RASIP1	RAP2A
Description		Ras interacting protein 1	RAP2A, member of RAS oncogene family
Image
GO Annotations	Cellular Component	Golgi Stack Cell-cell Junction Protein-containing Complex Perinuclear Region Of Cytoplasm	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Protein Binding Protein Homodimerization Activity GTPase Binding	Magnesium Ion Binding GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Integrin Activation Negative Regulation Of Rho Protein Signal Transduction Regulation Of GTPase Activity Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Membrane Permeability Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Cellular Response To Xenobiotic Stimulus Protein Localization To Plasma Membrane
Pathways
Drugs			Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol use disorder (total score) ( 30336701) Apolipoprotein A1 levels ( 33730874) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 21926972) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cooked vegetable consumption ( 32066663) Crohn's disease ( 28067908 21102463) Dietary macronutrient intake ( 23372041) Estimated glomerular filtration rate ( 31015462) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean platelet volume ( 32888494 27863252) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Retinal vascular caliber ( 21060863) Urinary albumin-to-creatinine ratio ( 31511532) Vitamin B levels in ischemic stroke ( 25147783) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)
Interacting Genes		8 interacting genes: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2	34 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B CDK4 EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D IRS2 MAP4K4 NEDD4 PLG RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGL1 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK
Entrez ID		54922	5911
HPRD ID		15214	01547
Ensembl ID		ENSG00000105538	ENSG00000125249
Uniprot IDs		Q5U651 Q7L251 Q8IUR2	P10114
PDB IDs		5KHO 5KHQ	1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?
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