RAP2A and RALGDS

Number of citations of the paper that reports this interaction (PubMedID 11786539)
41

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		RAP2A	RALGDS
Description		RAP2A, member of RAS oncogene family	ral guanine nucleotide dissociation stimulator
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane	Nucleus Cytosol Brush Border
	Molecular Function	Magnesium Ion Binding GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Cellular Response To Xenobiotic Stimulus Protein Localization To Plasma Membrane	Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity
Pathways			p38MAPK events p38MAPK events RAF/MAP kinase cascade
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		34 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B CDK4 EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D IRS2 MAP4K4 NEDD4 PLG RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGL1 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK	27 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2 ZMYND10
Entrez ID		5911	5900
HPRD ID		01547	03371
Ensembl ID		ENSG00000125249	ENSG00000160271
Uniprot IDs		P10114	Q12967 Q8N4Y1
PDB IDs		1KAO 2RAP 3RAP	1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?
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