RNF43 and MKS1

		RNF43	MKS1
Description		ring finger protein 43	MKS transition zone complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Centrosome Centriole Cytosol Membrane MKS Complex Ciliary Basal Body
	Molecular Function	Ubiquitin-protein Transferase Activity Frizzled Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of Wnt Signaling Pathway Wnt Receptor Catabolic Process Stem Cell Proliferation	Neural Tube Closure Smoothened Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Determination Of Left/right Symmetry Epithelial Structure Maintenance Embryonic Digit Morphogenesis Motile Cilium Assembly Embryonic Skeletal System Development Branching Morphogenesis Of An Epithelial Tube Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Head Development Cardiac Septum Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Common Bile Duct Development Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Non-motile Cilium Assembly Embryonic Brain Development Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		Regulation of FZD by ubiquitination Signaling by RNF43 mutants	Hedgehog 'off' state Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		Circulating myeloperoxidase levels (plasma) ( 23620142) Cognitive function ( 25644384) Hemoglobin levels ( 32327693) Iron status biomarkers (ferritin levels) ( 33536631) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Pancreatic cancer ( 20686608) Prostate cancer ( 29892016) Refractive error ( 32231278) Stroke ( 29531354) Vitamin D levels ( 25208829)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		9 interacting genes: MKS1 RSPO2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N	7 interacting genes: ABCC3 CACNA1G DDX24 DGKE RNF43 SMG8 TMEM67
Entrez ID		54894	54903
HPRD ID		07896	07900
Ensembl ID		ENSG00000108375	ENSG00000011143
Uniprot IDs		J3KSE3 Q68DV7	A0A0S2Z5Z2 A0A7I2V2M0 B4DVC5 H0Y2S2 J3KSC6 Q9NXB0
PDB IDs		4KNG
Enriched GO Terms of Interacting Partners?
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