PPP1R12C and ATP6V1H

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PPP1R12C	ATP6V1H
Description		protein phosphatase 1 regulatory subunit 12C	ATPase H+ transporting V1 subunit H
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton	Vacuolar Proton-transporting V-type ATPase, V1 Domain Lysosomal Membrane Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Phosphatase Regulator Activity Protein Kinase Binding	Protein Binding ATP Hydrolysis Activity Enzyme Regulator Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Signal Transduction Negative Regulation Of Catalytic Activity	Endocytosis Vacuolar Acidification Regulation Of Macroautophagy Regulation Of Catalytic Activity Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Nef Mediated CD4 Down-regulation Nef Mediated CD8 Down-regulation Insulin receptor recycling Transferrin endocytosis and recycling Blockage of phagosome acidification Amino acids regulate mTORC1 Ion channel transport
Drugs			Tiludronic acid
Diseases
GWAS			Bipolar disorder with mood-incongruent psychosis ( 23092984) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		27 interacting genes: ATP6V1H ATXN7 BHLHA9 C1orf109 CACNA1A CCDC185 CDC42BPA EHHADH EXOC3 FMR1 FXR1 FXR2 IL16 IMP3 MPRIP MYL2 NOD2 NXF1 PAFAH1B2 PPP1CB RBM17 SMAD3 SMARCA2 SPECC1L THOC1 TSFM USHBP1	10 interacting genes: ATP6V1E1 CDKN2B ETHE1 FLACC1 PPP1R12C SNPH SOX9 SPATA2 TANK TRIM14
Entrez ID		54776	51606
HPRD ID		11452	10591
Ensembl ID		ENSG00000125503	ENSG00000047249
Uniprot IDs		Q9BZL4	A0A024R7U9 A0A024R7X3 B3KUZ7 Q9UI12
PDB IDs			6WM2 6WM3 6WM4
Enriched GO Terms of Interacting Partners?
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