EXOSC10 and EIF3M

Number of citations of the paper that reports this interaction (PubMedID 15231747)
57

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EXOSC10	EIF3M
Description		exosome component 10	eukaryotic translation initiation factor 3 subunit M
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Transcriptionally Active Chromatin	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Nucleotide Binding 3'-5'-exoribonuclease Activity RNA Binding Single-stranded RNA Binding Exoribonuclease Activity Protein Binding Telomerase RNA Binding	Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Histone MRNA Catabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing Regulation Of Telomerase RNA Localization To Cajal Body	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translational Initiation
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998)	Menopause (age at onset) ( 26414677) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		37 interacting genes: ALDH1B1 B9D1 CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 NOMO1 NOMO2 PALS2 PTGES2 RPE RUVBL2 SCRIB SKIV2L SSRP1 SUMO2 TARDBP TOX4 TTN UPF2 USP16 USP21 XRN1 XRN2	10 interacting genes: ABI3 APP EIF3F EXOSC10 HSPB1 METTL3 SRPK1 TRIML2 ZMYND10 ZNF783
Entrez ID		5394	10480
HPRD ID		16180	09969
Ensembl ID		ENSG00000171824	ENSG00000149100
Uniprot IDs		Q01780	Q7L2H7
PDB IDs		2CPR 3SAF 3SAG 3SAH 6D6Q 6D6R	3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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