EIF3M and METTL3

Number of citations of the paper that reports this interaction (PubMedID 30232453)
165

Data Source:
BioGRID (pull down)

		EIF3M	METTL3
Description		eukaryotic translation initiation factor 3 subunit M	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleus Nucleoplasm Cytoplasm Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex
	Molecular Function	Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding	MRNA (N6-adenosine)-methyltransferase Activity MRNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity MRNA (2'-O-methyladenosine-N6-)-methyltransferase Activity Protein Heterodimerization Activity S-adenosyl-L-methionine Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translational Initiation	MRNA Splicing, Via Spliceosome RNA Methylation Adenosine To Inosine Editing MRNA Processing MRNA Catabolic Process Cellular Response To DNA Damage Stimulus Spermatogenesis Circadian Rhythm Dosage Compensation By Inactivation Of X Chromosome Stem Cell Population Maintenance Forebrain Radial Glial Cell Differentiation Primary MiRNA Processing Cellular Response To UV Gliogenesis Innate Immune Response Regulation Of T Cell Differentiation Positive Regulation Of Translation Negative Regulation Of Notch Signaling Pathway Oogenesis Regulation Of Meiotic Cell Cycle Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization MRNA Methylation Endothelial To Hematopoietic Transition Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Cap-independent Translational Initiation Primary MiRNA Methylation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Menopause (age at onset) ( 26414677) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Response to Homoharringtonine (cytotoxicity) ( 25628645)
Interacting Genes		10 interacting genes: ABI3 APP EIF3F EXOSC10 HSPB1 METTL3 SRPK1 TRIML2 ZMYND10 ZNF783	9 interacting genes: EIF3G EIF3I EIF3J EIF3M MAPK1 MAPK14 MAPK8 MTDH USP5
Entrez ID		10480	56339
HPRD ID		09969	14389
Ensembl ID		ENSG00000149100	ENSG00000165819
Uniprot IDs		Q7L2H7	Q86U44
PDB IDs		3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09	5IL0 5IL1 5IL2 5K7M 5K7U 5K7W 5L6D 5L6E 5TEY 5YZ9 6TTP 6TTT 6TTV 6TTW 6TTX 6TU1 6Y4G 7ACD
Enriched GO Terms of Interacting Partners?
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