PPIL3 and WDR12

		PPIL3	WDR12
Description		peptidylprolyl isomerase like 3	WD repeat domain 12
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GO Annotations	Cellular Component	Catalytic Step 2 Spliceosome	Nucleoplasm Nucleolus Preribosome, Large Subunit Precursor PeBoW Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Notch Signaling Pathway Ribosomal Large Subunit Biogenesis Regulation Of Cell Cycle
Pathways		mRNA Splicing - Major Pathway	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Ischemic stroke (small-vessel) ( 29531354) Lacunar stroke ( 33773637) Myocardial infarction (early onset) ( 19198609) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547) White matter integrity (fractional anisotropy) ( 32358547)
Interacting Genes		16 interacting genes: ALS2 CDK11B CENATAC MAIP1 MOB4 NOP58 NUP107 PCBP1 SHARPIN SLU7 SPATS2L SRPK1 STRADB TAB2 TAB3 WDR12	3 interacting genes: H1-2 NOTCH1 PPIL3
Entrez ID		53938	55759
HPRD ID		15163	18295
Ensembl ID		ENSG00000240344	ENSG00000138442
Uniprot IDs		A0A024R3V4 A0A0S2Z5A8 Q9H2H8	Q53T99 Q9GZL7
PDB IDs		1XYH 2OJU 2OK3	6N31 6P0Q
Enriched GO Terms of Interacting Partners?
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