PPIL3 and ALS2

		PPIL3	ALS2
Description		peptidylprolyl isomerase like 3	alsin Rho guanine nucleotide exchange factor ALS2
Image			No pdb structure
GO Annotations	Cellular Component	Catalytic Step 2 Spliceosome	Ruffle Nucleus Early Endosome Centrosome Cytosol Postsynaptic Density Membrane Lamellipodium Dendrite Growth Cone Vesicle Protein-containing Complex Neuronal Cell Body Dendritic Spine
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding	Behavioral Fear Response In Utero Embryonic Development Receptor Recycling Response To Oxidative Stress Endosome Organization Lysosomal Transport Axonogenesis Neuromuscular Junction Development Locomotory Behavior Protein Localization Cell Death Endosomal Transport Rac Protein Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Synaptic Transmission, Glutamatergic Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Neuron Projection Morphogenesis Regulation Of Endosome Size Protein Homooligomerization Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		mRNA Splicing - Major Pathway	RAB GEFs exchange GTP for GDP on RABs RAC1 GTPase cycle
Drugs
Diseases
GWAS		Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)	Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Perceived intensity of sweet substances ( 31005972)
Interacting Genes		16 interacting genes: ALS2 CDK11B CENATAC MAIP1 MOB4 NOP58 NUP107 PCBP1 SHARPIN SLU7 SPATS2L SRPK1 STRADB TAB2 TAB3 WDR12	4 interacting genes: IMPDH2 PPIL3 SUN2 YWHAB
Entrez ID		53938	57679
HPRD ID		15163	05893
Ensembl ID		ENSG00000240344	ENSG00000003393
Uniprot IDs		A0A024R3V4 A0A0S2Z5A8 Q9H2H8	A8K4R4 Q96Q42
PDB IDs		1XYH 2OJU 2OK3
Enriched GO Terms of Interacting Partners?
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