WDR12 and H1-2

Number of citations of the paper that reports this interaction (PubMedID 18258596)
53

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		WDR12	H1-2
Description		WD repeat domain 12	H1.2 linker histone, cluster member
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Preribosome, Large Subunit Precursor PeBoW Complex	Nucleosome Euchromatin Nucleus Transcriptionally Active Chromatin
	Molecular Function	Protein Binding Ribonucleoprotein Complex Binding	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Notch Signaling Pathway Ribosomal Large Subunit Biogenesis Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Negative Regulation Of DNA Recombination Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Ischemic stroke (small-vessel) ( 29531354) Lacunar stroke ( 33773637) Myocardial infarction (early onset) ( 19198609) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 32358547) White matter integrity (fractional anisotropy) ( 32358547)
Interacting Genes		3 interacting genes: H1-2 NOTCH1 PPIL3	29 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 HELLS IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 SNCA VHL WDR12 YBX1
Entrez ID		55759	3006
HPRD ID		18295	07514
Ensembl ID		ENSG00000138442	ENSG00000187837
Uniprot IDs		Q53T99 Q9GZL7	P16403
PDB IDs		6N31 6P0Q
Enriched GO Terms of Interacting Partners?
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