PNOC and OPRL1

Number of citations of the paper that reports this interaction (PubMedID 11097863)
17

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo)

		PNOC	OPRL1
Description		prepronociceptin	opioid related nociceptin receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Dendrite Neuronal Cell Body Axon Terminus	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Neuron Projection
	Molecular Function	Opioid Peptide Activity Neuropeptide Hormone Activity Opioid Receptor Binding	Nociceptin Receptor Activity G Protein-coupled Receptor Activity Protein Binding Protein C-terminus Binding Peptide Binding Neuropeptide Binding
	Biological Process	Signal Transduction Neuropeptide Signaling Pathway Chemical Synaptic Transmission Female Pregnancy Sensory Perception	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Sensory Perception Of Pain Response To Estradiol Positive Regulation Of Urine Volume G Protein-coupled Opioid Receptor Signaling Pathway Eating Behavior Negative Regulation Of CAMP-mediated Signaling Estrous Cycle Negative Regulation Of Blood Pressure Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Gastric Acid Secretion Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Sensory Perception Of Pain Regulation Of Locomotor Rhythm Conditioned Place Preference
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Buprenorphine Etorphine Epicept NP-1
Diseases
GWAS		Body mass index ( 28892062) Daytime nap ( 33568662) Metabolite levels ( 23823483)	Body shape index ( 34021172) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) HDL cholesterol levels ( 32203549) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: FBXO7 OPRL1	10 interacting genes: CERS6 DNAJC30 GNA14 GPRASP1 HLA-C OPRM1 PLLP PNOC RGS19 SLC31A2
Entrez ID		5368	4987
HPRD ID		03268	03971
Ensembl ID		ENSG00000168081	ENSG00000125510
Uniprot IDs		Q13519	A0A5F9ZI64 P41146 Q8IXB0
PDB IDs			4EA3 5DHG 5DHH
Enriched GO Terms of Interacting Partners?
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