OPRL1 and RGS19

Number of citations of the paper that reports this interaction (PubMedID 11090272)
9

Data Source:
HPRD (in vitro, in vivo)

		OPRL1	RGS19
Description		opioid related nociceptin receptor 1	regulator of G protein signaling 19
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Neuron Projection	Golgi Apparatus Plasma Membrane Brush Border Membrane Clathrin-coated Vesicle Membrane Raft
	Molecular Function	Nociceptin Receptor Activity G Protein-coupled Receptor Activity Protein Binding Protein C-terminus Binding Peptide Binding Neuropeptide Binding	G-protein Alpha-subunit Binding GTPase Activity Protein Binding
	Biological Process	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Sensory Perception Of Pain Response To Estradiol Positive Regulation Of Urine Volume G Protein-coupled Opioid Receptor Signaling Pathway Eating Behavior Negative Regulation Of CAMP-mediated Signaling Estrous Cycle Negative Regulation Of Blood Pressure Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Gastric Acid Secretion Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Sensory Perception Of Pain Regulation Of Locomotor Rhythm Conditioned Place Preference	Autophagy G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Negative Regulation Of Signal Transduction Response To Ethanol
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs		Buprenorphine Etorphine Epicept NP-1
Diseases
GWAS		Body shape index ( 34021172) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) HDL cholesterol levels ( 32203549) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronic kidney disease ( 31152163) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Systolic blood pressure ( 30578418)
Interacting Genes		10 interacting genes: CERS6 DNAJC30 GNA14 GPRASP1 HLA-C OPRM1 PLLP PNOC RGS19 SLC31A2	25 interacting genes: ALPP CATSPER1 CSNK2A1 CSNK2A2 GDE1 GIPC1 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ HOXA1 KRTAP5-6 LCE4A MAPK1 MAPK6 NUFIP2 OPRL1 OSTM1 OTX1 POU4F2 PRKCA PSMA1 TGFBR1 VASN
Entrez ID		4987	10287
HPRD ID		03971	05461
Ensembl ID		ENSG00000125510	ENSG00000171700
Uniprot IDs		A0A5F9ZI64 P41146 Q8IXB0	B4DP94 P49795
PDB IDs		4EA3 5DHG 5DHH	1CMZ
Enriched GO Terms of Interacting Partners?
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