OPRL1 and GNA14

Number of citations of the paper that reports this interaction (PubMedID 9862775)
9

Data Source:
HPRD (in vivo, in vitro)

		OPRL1	GNA14
Description		opioid related nociceptin receptor 1	G protein subunit alpha 14
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Neuron Projection	Heterotrimeric G-protein Complex Plasma Membrane Extracellular Exosome
	Molecular Function	Nociceptin Receptor Activity G Protein-coupled Receptor Activity Protein Binding Protein C-terminus Binding Peptide Binding Neuropeptide Binding	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Sensory Perception Of Pain Response To Estradiol Positive Regulation Of Urine Volume G Protein-coupled Opioid Receptor Signaling Pathway Eating Behavior Negative Regulation Of CAMP-mediated Signaling Estrous Cycle Negative Regulation Of Blood Pressure Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Gastric Acid Secretion Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Sensory Perception Of Pain Regulation Of Locomotor Rhythm Conditioned Place Preference	Action Potential Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		Buprenorphine Etorphine Epicept NP-1
Diseases
GWAS		Body shape index ( 34021172) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) HDL cholesterol levels ( 32203549) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Bipolar disorder ( 31043756) Delirium ( 29631748) Thoracic aortic calcification levels ( 31659325)
Interacting Genes		10 interacting genes: CERS6 DNAJC30 GNA14 GPRASP1 HLA-C OPRM1 PLLP PNOC RGS19 SLC31A2	9 interacting genes: ADRB2 CCR1 CHRM2 CXCR1 CXCR2 DNAL4 JMJD6 OPRL1 SSTR2
Entrez ID		4987	9630
HPRD ID		03971	05095
Ensembl ID		ENSG00000125510	ENSG00000156049
Uniprot IDs		A0A5F9ZI64 P41146 Q8IXB0	O95837
PDB IDs		4EA3 5DHG 5DHH
Enriched GO Terms of Interacting Partners?
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