OPRL1 and CERS6

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		OPRL1	CERS6
Description		opioid related nociceptin receptor 1	ceramide synthase 6
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Neuron Projection	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Nociceptin Receptor Activity G Protein-coupled Receptor Activity Protein Binding Protein C-terminus Binding Peptide Binding Neuropeptide Binding	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Sensory Perception Of Pain Response To Estradiol Positive Regulation Of Urine Volume G Protein-coupled Opioid Receptor Signaling Pathway Eating Behavior Negative Regulation Of CAMP-mediated Signaling Estrous Cycle Negative Regulation Of Blood Pressure Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Gastric Acid Secretion Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Sensory Perception Of Pain Regulation Of Locomotor Rhythm Conditioned Place Preference	Inflammatory Response Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Sphingolipid de novo biosynthesis
Drugs		Buprenorphine Etorphine Epicept NP-1
Diseases
GWAS		Body shape index ( 34021172) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) HDL cholesterol levels ( 32203549) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Bipolar disorder ( 31043756) Parkinson's disease ( 27182965) Recurrent major depressive disorder ( 34099189) Recurrent major depressive disorder x sex interaction ( 34099189) Red cell distribution width ( 32888494 27863252 28957414) Skin aging (microtopography measurement) ( 28502801) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)
Interacting Genes		10 interacting genes: CERS6 DNAJC30 GNA14 GPRASP1 HLA-C OPRM1 PLLP PNOC RGS19 SLC31A2	3 interacting genes: AGTR1 OPRL1 SEC22B
Entrez ID		4987	253782
HPRD ID		03971	17258
Ensembl ID		ENSG00000125510	ENSG00000172292
Uniprot IDs		A0A5F9ZI64 P41146 Q8IXB0	Q6ZMG9
PDB IDs		4EA3 5DHG 5DHH
Enriched GO Terms of Interacting Partners?
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