NCKIPSD and DIAPH3

Number of citations of the paper that reports this interaction (PubMedID 11509578)
29

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		NCKIPSD	DIAPH3
Description		NCK interacting protein with SH3 domain	diaphanous related formin 3
Image
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Myosin Binding SH3 Domain Binding Arp2/3 Complex Binding	Actin Binding Small GTPase Binding Cadherin Binding
	Biological Process	Endocytosis Cytoskeleton Organization Positive Regulation Of Neuron Projection Development	Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament Polymerization
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	RHO GTPases Activate Formins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Anorexia nervosa ( 31308545) Blood protein levels ( 28240269) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Myocardial infarction ( 33532862) Parkinson's disease ( 28892059) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	Age at first sexual intercourse ( 27089180 34211149) Body mass index ( 28892062) Breast milk fatty acid composition (infant genotype effect) ( 29514873) Breast milk fatty acid composition (maternal genotype effect) ( 29514873) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Gut microbiota (functional units) ( 27694959) HOMA-B (corrected for HOMA-IR) ( 30369944) Metabolite levels ( 23823483) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Number of sexual partners ( 30643258) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		42 interacting genes: ABI2 ARHGEF7 BAIAP2 CCDC187 CPNE2 CYSLTR2 DIAPH2 DIAPH3 DLG4 DMRTB1 ENKD1 FASLG GAS7 GRB2 HSPB1 ITGB1 KHDRBS1 LGALS4 MAPK3 MED25 NCK1 NCK2 PIN1 PKP2 POLR3C PRPF31 PSMD9 PSORS1C2 RBM22 RBP7 RXFP3 SHANK3 SNRPC SORBS3 STAC TSEN54 VEZF1 WAS WASL YWHAG ZBTB47 ZC2HC1C	6 interacting genes: CDC42 NCKIPSD PDCD6 RAC1 RHOA SMAD9
Entrez ID		51517	81624
HPRD ID		09450	10884
Ensembl ID		ENSG00000213672	ENSG00000139734
Uniprot IDs		Q9NZQ3	B4DPV3 Q9NSV4
PDB IDs		6DEC 6DED 6DEE	5UWP 6X2Y
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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