PCSK5 and DOCK2

  • Number of citations of the paper that reports this interaction (PubMedID 32296183)
  • 86
  • Data Source:
  • BioGRID (two hybrid)

PCSK5

DOCK2

Description proprotein convertase subtilisin/kexin type 5 dedicator of cytokinesis 2
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alzheimer's disease progression score ( 29860282)
  • Amyotrophic lateral sclerosis (age of onset) ( 22959728)
  • Ankylosing spondylitis ( 30946743)
  • Apolipoprotein B levels ( 32203549)
  • Body fat distribution (leg fat ratio) ( 30664634)
  • Body fat distribution (trunk fat ratio) ( 30664634)
  • Body shape index ( 34021172)
  • Diverticular disease ( 30177863)
  • Glucocorticoid-induced osteonecrosis ( 26265699)
  • Glucose homeostasis traits ( 25524916)
  • Height ( 28552196 20881960 25282103 23563607 31562340)
  • Hip circumference adjusted for BMI ( 34021172)
  • Hypotension and cognitive impairment ( 31362389)
  • Inflammatory bowel disease ( 27569725)
  • Intraocular pressure ( 29785010 31959993 30054594)
  • LDL cholesterol levels ( 32203549)
  • LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
  • LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
  • Lead levels ( 26025379)
  • Low density lipoprotein cholesterol levels ( 32154731)
  • Male fertility ( 22633400)
  • Metabolite levels (5-HIAA) ( 23319000)
  • Pursuit maintenance gain ( 29064472)
  • Response to fenofibrate (adiponectin levels) ( 23149075)
  • Schizophrenia, bipolar disorder or major depressive disorder ( 34099189)
  • Systemic sclerosis ( 30247649)
  • Takayasu arteritis ( 25604533)
  • Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
  • Vascular brain injury ( 25188341)
  • Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
  • Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
  • Waist circumference adjusted for BMI in non-smokers ( 28443625)
  • Waist circumference adjusted for body mass index ( 34021172 25673412)
  • Waist-hip index ( 34021172)
  • Weight ( 34074324)
  • Acne (severe) ( 24927181)
  • Body mass index and waist-hip ratio (pleiotropy) ( 29868124)
  • Coronary artery aneurysm in Kawasaki disease ( 33772158)
  • Placental abruption ( 29884306)
  • Pneumococcal bacteremia ( 27236921)
  • Prostate cancer ( 29892016)
  • Protein quantitative trait loci ( 18464913)
Interacting Genes 72 interacting genes: ADAMTSL4 AMH APPBP2 ATN1 C17orf50 C22orf39 CACNA1A CCDC33 CLIC1 CREB5 CYSRT1 DBF4B DEK DOCK2 FAM86C1P FARS2 FRS3 GLRX3 GUCD1 HOXA1 HOXB9 INCA1 ITGA6 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-9 LCE1D LCE1F LCE2C LCE3C LCE3D MDFI MEOX2 NBPF19 NOTCH2NLA NR1D2 NR4A3 NUFIP2 OTX1 PCSK6 PLSCR4 PMCH POU4F2 PTPRM REN SH3GLB1 SHFL SMCP SPRY1 SSC4D STK16 TEKT4 TLE5 TRAF4 TRIB3 TRIM42 TRIP13 USP54 VGLL3 ZNF547 ZNF655 ZNF837 49 interacting genes: CALCOCO2 CARD10 CCNDBP1 CD247 CRKL CYSRT1 ELMO1 GNAL GOLGA6L9 HNRNPK HOXA1 KHDRBS1 KHDRBS2 KHDRBS3 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP3-1 KRTAP3-3 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 MDFI MTDH MTUS2 NBPF19 NOTCH2NLA PAK2 PCSK5 PLEKHF2 PLSCR1 RAC1 RAC2 TENM4 TGM1 TRIM23 VAV1
Entrez ID 5125 1794
HPRD ID 08985 09121
Ensembl ID ENSG00000099139 ENSG00000134516
Uniprot IDs Q92824 Q5XG91 Q92608
PDB IDs 2RQR 2YIN 3A98 3B13 6TGB 6TGC
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?