DOCK2 and RAC2

Number of citations of the paper that reports this interaction (PubMedID 10559471)
24

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		DOCK2	RAC2
Description		dedicator of cytokinesis 2	Rac family small GTPase 2
Image
GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Membrane Specific Granule Lumen Extracellular Exosome	Nuclear Envelope Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding T Cell Receptor Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Small GTPase Mediated Signal Transduction Actin Cytoskeleton Organization Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Proliferation Positive Regulation Of Phagocytosis Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Rac Protein Signal Transduction Cell Projection Assembly Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Regulation Of Mast Cell Degranulation Engulfment Of Apoptotic Cell Bone Resorption Regulation Of Catalytic Activity Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Nef and signal transduction Neutrophil degranulation RHOA GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle Factors involved in megakaryocyte development and platelet production	GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RAC2 GTPase cycle
Drugs			Dextromethorphan
Diseases
GWAS		Acne (severe) ( 24927181) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Coronary artery aneurysm in Kawasaki disease ( 33772158) Placental abruption ( 29884306) Pneumococcal bacteremia ( 27236921) Prostate cancer ( 29892016) Protein quantitative trait loci ( 18464913)	Celiac disease ( 31591516) Graves' disease ( 23612905) Longevity ( 20834067) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)
Interacting Genes		49 interacting genes: CALCOCO2 CARD10 CCNDBP1 CD247 CRKL CYSRT1 ELMO1 GNAL GOLGA6L9 HNRNPK HOXA1 KHDRBS1 KHDRBS2 KHDRBS3 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP3-1 KRTAP3-3 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 MDFI MTDH MTUS2 NBPF19 NOTCH2NLA PAK2 PCSK5 PLEKHF2 PLSCR1 RAC1 RAC2 TENM4 TGM1 TRIM23 VAV1	24 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB BRD2 CDC42 CHGB CHPF CUL1 DEF6 DOCK2 GDI1 HDAC7 ICMT NCF2 NOS2 NOXA1 PAK2 RTKN SMAD1 SMAD4
Entrez ID		1794	5880
HPRD ID		09121	03628
Ensembl ID		ENSG00000134516	ENSG00000128340
Uniprot IDs		Q5XG91 Q92608	A0A024R1P2 P15153 V9H0H7
PDB IDs		2RQR 2YIN 3A98 3B13 6TGB 6TGC	1DS6 2W2T 2W2V 2W2X
Enriched GO Terms of Interacting Partners?
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