ITSN2 and GPNMB

Number of citations of the paper that reports this interaction (PubMedID 22558309)
25

Data Source:
BioGRID (two hybrid)

		ITSN2	GPNMB
Description		intersectin 2	glycoprotein nmb
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Plasma Membrane Clathrin-coated Pit Presynaptic Membrane Extracellular Exosome Intracellular Vesicle Presynapse	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Early Endosome Membrane Melanosome Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Molecular Adaptor Activity	Integrin Binding Protein Binding Heparin Binding Chemoattractant Activity Syndecan Binding Receptor Ligand Activity
	Biological Process	Endocytosis Endosomal Transport Cell Differentiation Regulation Of Catalytic Activity Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Dendrite Extension	Osteoblast Differentiation Negative Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Bone Mineralization Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Tissue Remodeling Negative Regulation Of T Cell Proliferation Regulation Of Angiogenesis Negative Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neuron Death Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOU GTPase cycle	PTK6 promotes HIF1A stabilization
Drugs			Glembatumumab vedotin
Diseases
GWAS		Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) SjÃ¶gren's syndrome ( 24097067) Total cholesterol levels ( 33339817)	Blood protein levels ( 30072576 29875488 28240269) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Iron status biomarkers (transferrin saturation) ( 28334935) Parkinson's disease ( 25064009 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		77 interacting genes: AGT AHDC1 AMPH ANKRD17 B4GALT2 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DST EGFR EPS15L1 EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RAD9A RBMX REPS1 RNF20 ROCK1 RRM2 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1	5 interacting genes: EGFR GSDME ITSN2 LINC01139 SMAD4
Entrez ID		50618	10457
HPRD ID		09193	05081
Ensembl ID		ENSG00000198399	ENSG00000136235
Uniprot IDs		A6H8W8 Q9NZM3	A0A024RA55 Q14956 Q96F58
PDB IDs		1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?