GPNMB

Description		glycoprotein nmb
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Early Endosome Membrane Melanosome Membrane
	Molecular Function	Integrin Binding Protein Binding Heparin Binding Chemoattractant Activity Syndecan Binding Receptor Ligand Activity
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Bone Mineralization Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Tissue Remodeling Negative Regulation Of T Cell Proliferation Regulation Of Angiogenesis Negative Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neuron Death Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		PTK6 promotes HIF1A stabilization
Drugs		Glembatumumab vedotin
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Iron status biomarkers (transferrin saturation) ( 28334935) Parkinson's disease ( 25064009 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		5 interacting genes: EGFR GSDME ITSN2 LINC01139 SMAD4
Entrez ID		10457
HPRD ID		05081
Ensembl ID		ENSG00000136235
Uniprot IDs		A0A024RA55 Q14956 Q96F58
PDB IDs
Enriched GO Terms of Interacting Partners?
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