GPNMB and GSDME

		GPNMB	GSDME
Description		glycoprotein nmb	gasdermin E
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Early Endosome Membrane Melanosome Membrane	Cytoplasm Cytosol Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Integrin Binding Protein Binding Heparin Binding Chemoattractant Activity Syndecan Binding Receptor Ligand Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cardiolipin Binding
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Bone Mineralization Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Tissue Remodeling Negative Regulation Of T Cell Proliferation Regulation Of Angiogenesis Negative Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neuron Death Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Sensory Perception Of Sound Cell Death Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Inner Ear Receptor Cell Differentiation Necrotic Cell Death Pyroptosis Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		PTK6 promotes HIF1A stabilization	Release of apoptotic factors from the mitochondria Pyroptosis Regulation of TLR by endogenous ligand Defective pyroptosis
Drugs		Glembatumumab vedotin
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Iron status biomarkers (transferrin saturation) ( 28334935) Parkinson's disease ( 25064009 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		5 interacting genes: EGFR GSDME ITSN2 LINC01139 SMAD4	11 interacting genes: AHR C1GALT1 GARS1 GP1BB GPNMB HNRNPA2B1 ITGB1BP1 PTN TBX19 TIFA VPS41
Entrez ID		10457	1687
HPRD ID		05081	02996
Ensembl ID		ENSG00000136235	ENSG00000105928
Uniprot IDs		A0A024RA55 Q14956 Q96F58	A0A024RA58 A4FVA8 O60443
PDB IDs
Enriched GO Terms of Interacting Partners?
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