PAK1 and ARHGEF7

Number of citations of the paper that reports this interaction (PubMedID 10330411)
158

Data Source:
HPRD (in vivo, in vitro)

		PAK1	ARHGEF7
Description		p21 (RAC1) activated kinase 1	Rho guanine nucleotide exchange factor 7
Image
GO Annotations	Cellular Component	Ruffle Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Cytosol Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Z Disc Lamellipodium Axon Dendrite Nuclear Membrane Ruffle Membrane Protein-containing Complex	Ruffle Centrosome Cytosol Focal Adhesion Cell Cortex Lamellipodium Protein-containing Complex Neuron Projection Neuronal Cell Body Mitotic Spindle Pole Postsynapse
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Kinase Binding Small GTPase Binding Gamma-tubulin Binding Protein Serine Kinase Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Gamma-tubulin Binding
	Biological Process	MAPK Cascade Response To Hypoxia Positive Regulation Of Protein Phosphorylation Stimulatory C-type Lectin Receptor Signaling Pathway Chromatin Remodeling Protein Phosphorylation Exocytosis Apoptotic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Positive Regulation Of Fibroblast Migration Phosphorylation Cell Migration Cerebellum Development Establishment Of Cell Polarity Positive Regulation Of Cell Migration Positive Regulation Of Microtubule Polymerization Actin Cytoskeleton Reorganization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Positive Regulation Of Axon Extension Positive Regulation Of Insulin Receptor Signaling Pathway Protein Autophosphorylation Hepatocyte Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis Regulation Of Axonogenesis Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Microtubule Nucleation Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Golgi Organization Signal Transduction Nervous System Development Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of GTP Binding Negative Regulation Of Microtubule Nucleation Positive Regulation Of Lamellipodium Morphogenesis
Pathways		Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation FCERI mediated MAPK activation FCERI mediated MAPK activation DSCAM interactions CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 Signal transduction by L1 Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PKNs RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	EGFR downregulation NRAGE signals death through JNK Ephrin signaling G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)	Bilirubin levels ( 19414484) Choroid plexus volume ( 31530798) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Macular thickness ( 30535121) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619) Skin aging measurement ( 31522824) Weight ( 34074324)
Interacting Genes		85 interacting genes: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BMPR1B BMX BRSK1 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CPLANE1 CSNK2A1 CSNK2A2 DSCAM DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 H3C1 H4C1 HACE1 HGS HSP90AA1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1A PPM1F PPP1CA PPP2CA PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83	36 interacting genes: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 EGFR ERBIN FXR1 FXR2 GIT1 GIT2 HSPB1 ITCH LRRK2 MEOX2 NCK1 NCKIPSD NOX1 PAK1 PAK2 PAK3 PPM1E PPM1F PRKCG PRRG4 PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG
Entrez ID		5058	8874
HPRD ID		03995	05688
Ensembl ID		ENSG00000149269	ENSG00000102606
Uniprot IDs		A0A024R5P0 Q13153	A0A024RDY9 B7Z344 B7Z6G2 E9PDQ5 Q14155 Q5W9H1
PDB IDs		1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90 4ZJI 4ZJJ 4ZLO 4ZY4 4ZY5 4ZY6 5DEW 5DEY 5DFP 5IME 5KBQ 5KBR 6B16	1BY1 1ZSG 2L3G 5SXP
Enriched GO Terms of Interacting Partners?
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