PAK1 and HACE1

  • Number of citations of the paper that reports this interaction (PubMedID 29362425)
  • 5
  • Data Source:
  • BioGRID (enzymatic study)

PAK1

HACE1

Description p21 (RAC1) activated kinase 1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adult body size ( 32376654)
  • Age at first sexual intercourse ( 34211149)
  • Age at voice drop ( 27182965)
  • Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
  • Feeling guilty ( 29500382)
  • Height ( 18391951)
  • Hip circumference adjusted for BMI ( 34021172)
  • Intraocular pressure ( 29617998)
  • Major depressive disorder ( 27479909)
  • Menarche (age at onset) ( 19448622 27182965)
  • Multiple sclerosis ( 23412934)
  • Neuroblastoma ( 22941191)
  • Obsessive-compulsive disorder ( 22889921)
  • Resistant hypertension ( 31545351)
  • Schizophrenia ( 28991256)
  • Sporadic neuroblastoma ( 28545128)
  • Thyroid stimulating hormone levels ( 17903292)
  • Type 2 diabetes ( 31049640)
  • Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500)
  • Waist circumference adjusted for BMI in active individuals ( 28448500)
  • Waist circumference adjusted for BMI in inactive individuals ( 28448500)
  • Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes 85 interacting genes: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BMPR1B BMX BRSK1 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CPLANE1 CSNK2A1 CSNK2A2 DSCAM DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 H3C1 H4C1 HACE1 HGS HSP90AA1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1A PPM1F PPP1CA PPP2CA PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83 9 interacting genes: MTDH OPTN PAK1 PLXNA2 RAB4A RAC1 SNTG2 UBE2D2 UBE2L3
Entrez ID 5058 57531
HPRD ID 03995 17086
Ensembl ID ENSG00000149269 ENSG00000085382
Uniprot IDs A0A024R5P0 Q13153 Q8IYU2
PDB IDs 1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC 4O0R 4O0T 4P90 4ZJI 4ZJJ 4ZLO 4ZY4 4ZY5 4ZY6 5DEW 5DEY 5DFP 5IME 5KBQ 5KBR 6B16
Enriched GO Terms of Interacting Partners?
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