ARHGEF7 and PRRG4

Number of citations of the paper that reports this interaction (PubMedID 23873930)
7

Data Source:
BioGRID (pull down)

		ARHGEF7	PRRG4
Description		Rho guanine nucleotide exchange factor 7	proline rich and Gla domain 4
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Centrosome Cytosol Focal Adhesion Cell Cortex Lamellipodium Protein-containing Complex Neuron Projection Neuronal Cell Body Mitotic Spindle Pole Postsynapse	Extracellular Region Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Gamma-tubulin Binding	Molecular_function Calcium Ion Binding Protein Binding WW Domain Binding
	Biological Process	Golgi Organization Signal Transduction Nervous System Development Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of GTP Binding Negative Regulation Of Microtubule Nucleation Positive Regulation Of Lamellipodium Morphogenesis	Biological_process
Pathways		EGFR downregulation NRAGE signals death through JNK Ephrin signaling G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle
Drugs
Diseases
GWAS		Bilirubin levels ( 19414484) Choroid plexus volume ( 31530798) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Macular thickness ( 30535121) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619) Skin aging measurement ( 31522824) Weight ( 34074324)	Parkinson's disease (age of onset) ( 19772629) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		36 interacting genes: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 EGFR ERBIN FXR1 FXR2 GIT1 GIT2 HSPB1 ITCH LRRK2 MEOX2 NCK1 NCKIPSD NOX1 PAK1 PAK2 PAK3 PPM1E PPM1F PRKCG PRRG4 PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG	32 interacting genes: ABL2 AOC3 ARHGEF7 BCL10 CYGB ERBB3 ERBB4 FYN GRAP GRB2 HCK HDAC1 HECW1 HLA-C ITCH ITSN1 LYN MAGI1 MAGI2 MAGI3 NEBL NEDD4L OSTF1 PEX13 RBBP8 TEC UBE2K VAV2 VEGFA WWP1 WWTR1 YAP1
Entrez ID		8874	79056
HPRD ID		05688	15187
Ensembl ID		ENSG00000102606	ENSG00000135378
Uniprot IDs		A0A024RDY9 B7Z344 B7Z6G2 E9PDQ5 Q14155 Q5W9H1	A0A0S2Z5N9 Q9BZD6
PDB IDs		1BY1 1ZSG 2L3G 5SXP
Enriched GO Terms of Interacting Partners?
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